Version Compatibility

Reference examples tested with: BioPython 1.83+, Entrez Direct 21.0+

Before using code patterns, verify installed versions match. If versions differ:

• Python: pip show <package> then help(module.function) to check signatures

If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying.

dbSNP Queries

"Look up variant information by rsID" → Retrieve variant annotations, genomic coordinates, and cross-references to ClinVar/gnomAD from dbSNP using REST API queries.

• Python: myvariant.MyVariantInfo().getvariant('rs12345')

Query rsID via myvariant.info

Goal: Retrieve variant information including dbSNP, ClinVar, and gnomAD annotations by rsID.

Approach: Query myvariant.info with the rsID and request specific annotation fields.

import myvariant

mv = myvariant.MyVariantInfo()

def get_rsid_info(rsid):
    '''Get variant info by rsID'''
    result = mv.getvariant(rsid, fields=['dbsnp', 'clinvar', 'gnomad_exome'])
    return result

result = get_rsid_info('rs121913527')

Query via NCBI Entrez

Goal: Search and fetch dbSNP records directly from NCBI using Entrez E-utilities.

Approach: Use BioPython Entrez esearch to find SNP IDs, then efetch to retrieve full XML records.

from Bio import Entrez
import xml.etree.ElementTree as ET

Entrez.email = '[email protected]'

def search_dbsnp(rsid):
    '''Search dbSNP by rsID'''
    handle = Entrez.esearch(db='snp', term=rsid)
    record = Entrez.read(handle)
    handle.close()
    return record

def fetch_dbsnp(snp_id):
    '''Fetch dbSNP record by internal ID'''
    handle = Entrez.efetch(db='snp', id=snp_id, rettype='xml')
    xml_data = handle.read()
    handle.close()
    return xml_data